Stressors such as foot shock and restraint induce neuronal activation, as measured by c-Fos, in anxiety-related regions including the DR, amygdala, and BNST while at the same time also increasing mRNA for CRF in the BNST and CE, suggesting that anxiety- or fear-inducing stimuli alter CRF function while activating neurons in the DR (Funk et al., 2006). The gene discussed is FOS; the disease is Anxiety.