Additionally, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT7 receptors have been implicated in playing a role in emotional behaviors in the BNST, with the 5-HT1 receptor activation linked to reduced anxiety and the others linked to increased anxiety (Levita et al., 2004; Guo et al., 2009; Hammack et al., 2009; Guo and Rainnie, 2010). This evidence concerns the gene HTR1B and Anxiety.