Overexpression of Rad51 has been observed in several cancers and may be involved in either the initiation or the progression of tumorigenesis.18,19 In non-small cell lung cancer (NSCLC), overexpression of Rad51 is related to decreased survival and increased tumor cell survival.15 Overexpression of Rad51 has been reported to correlate with histological grading of sporadic invasive ductal breast cancer, and is more frequently observed in advanced prostate cancer.18,19 These results suggest a relationship between Rad51 overexpression and more aggressive tumor behavior. This evidence concerns the gene RAD51 and Familial prostate cancer.