CFTR and cystic fibrosis: The currently available CF mouse models can be broadly classified into three main categories: (1) mouse models with a complete knockout of the Cftr gene which contain mutations that result in a complete loss of function [105]; (2) mouse models retaining the potential for reversion to wild-type, generated using an “insertional strategy” into the target gene [106]; and (3) the later-in-time generated recombinant CF mouse-models which contain clinically relevant mutations in Cftr, created by introducing specific human mutations, including the ΔF508 and G551D into the equivalent mouse loci.