FMO5 and ischemia: Actually, in Wistar Kyoto rats an optimal concentration of ROS allows the coronary collateral growth in response to repetitive ischemia, a phenomenon blunted by inhibitors of both mitochondrial electron transport chain and NADPH oxidase [49], whereas in OZR the baseline elevated oxidative stress due to mitochondrial dysfunction abrogates the process of coronary collateral growth in response to repetitive ischemia, which is restored by the elimination of the mitochondrial oxidative stress [22].