Mutations in the F-box protein 7 gene (FBXO7), encoding a protein of the F-box protein family, have been identified as a cause for Parkinsonian-pyramidal syndrome, an autosomal recessive neurodegenerative disease with severe levodopa-responsive Parkinsonism, and additional pyramidal signs[9]. The gene discussed is FBXO7; the disease is neurodegenerative disease.