In addition, immunohistochemistry (IHC) performed in tissue microarrays confirmed that FBP2 protein expression was also decreased in GC tissues, with 86.2% (100/116) of tumour tissues having low FBP2 expression and only 42.7% (47/110) of adjacent normal tissues having low FBP2 expression (Additional file 1: Figure S1, Table 1, P < 0.001). This evidence concerns the gene FBP2 and neoplasm.