Our results suggest that CAWS administration induces non-lethal CAWS-vasculitis in both B6 and DBA/2 mice via a Dectin-2 pathway, but induces enhanced expression of Ifng only in DBA/2 mice, which leads to augmented expression of C3, C4, Cfb, Cfh, and Fcna, thereby causing lethal inflammation of the arteries and severe vasculitis. Here, C4A is linked to vasculitis.