FOXP3 and Cowden disease: On the contrary, Ricciardelli et al. recently demonstrated that in gut lamina propria of children affected by active CD, there is a reduced number of FOXP3+ cells compared with controls and that the frequency of Tregs and their FOXP3 expression may increase in CD children treated in vivo with infliximab compared with the mucosa of untreated CD children and controls [29].