In melanoma, the arrangement of the TATA-box, binding and initiator sites, and enhancer sequences in the HERV-K proviral LTR have been shown to play an important role in the reactivation of the provirus via binding of melanoma-specific isoform of microphthalmia-associated transcription factor (MITF-M) to the proviral LTR (27). Here, MITF is linked to melanoma.