Genetic inactivation of PKCζ in mice was reported to result in invasive prostate carcinomas in vivo, which was associated with increased cell growth, invasion, and metastasis; these findings revealed that the phosphorylation of c-Myc on Ser-373 by PKCζ is necessary and sufficient to repress c-Myc-activity (33). Here, MYC is linked to prostate carcinoma.