Elevated levels of activated-NF-κB induce cyclin D gene transcription and cell cycle progression, activation of anti-apoptotic genes bcl-2 and bcl-xL, expression of vascular endothelial growth factor and consequent tumor angiogenesis, activation of transcription factor c-myc, metalloproteinase gene expression, and remodeling of the extra-cellular matrix (72, –74). The gene discussed is NFKB1; the disease is neoplasm.