Our preliminary results also suggest that in the context of adoptive T cell therapy after hematopoietic stem cell transplantation (70, 71), NGR-TNF dramatically increases the infiltration of TILs into the prostate of mice affected by autochthonous prostate cancer (49) and contributes to tumor debulking (Mondino A. Personal communication). This evidence concerns the gene TNF and Familial prostate cancer.