According to previous studies, c-Myc, GLI1, cyclin D1, Cav-1, VEGFA, IGF1, NKX2-2, AURKA, EZH2, and NR0B1 are among the downstream targets of EWS-FLI1 that are upregulated in ES to promote cell survival and proliferation (53–56). The gene discussed is EWSR1; the disease is Ewing sarcoma.