MITF and lentigo maligna melanoma: We show two representative melanoma tissues (MM and lentigo maligna melanoma) where cells more distal to the epidermal surface showed a lower intensity of MITF expression relative to PAX3 expression, and a change in color saturation was observed in melanoma cells more distal to the epidermal surface compared to cells immediately below the epidermal surface (Figures 2A,B).