We show two representative melanoma tissues (MM and lentigo maligna melanoma) where cells more distal to the epidermal surface showed a lower intensity of MITF expression relative to PAX3 expression, and a change in color saturation was observed in melanoma cells more distal to the epidermal surface compared to cells immediately below the epidermal surface (Figures 2A,B). Here, MITF is linked to melanoma.