PAX3 and melanoma: Our RNAi data in Figure 4 suggest that PAX3 and MITF expression contribute in distinct ways to cell migration, leading to the suggestion that it is the relative strengths of signals in the PAX3-POU3F2 axis versus the MITF-miR-211 axis that define the strength of lineage commitment in melanoma cells, and the migratory behavior of the melanoma cells.