In this study, we aimed to investigate the distribution of γδ T cells in the peripheral blood of SLE patients and its relation to disease activity and to analyze the apoptotic status, proliferation ability, and intracellular cytokine profile, including IFN-γ, IL-4, IL-10, IL-17, and TGF-β, in these γδ T cells. The gene discussed is TGFB1; the disease is systemic lupus erythematosus.