TNFSF10 and melanoma: Genes involved in Apo2L/TRAIL signaling, including TRAIL, the TRAIL receptor DR4, RASSF1A, and XAF1 are epigenetically silenced in melanomas (Reu et al., 2006a, b; Bae et al., 2008), leukemia (Soncini et al., 2013), renal carcinoma (Reu et al., 2006a) and experimentally transformed cells (Lund et al., 2011).