Genes involved in Apo2L/TRAIL signaling, including TRAIL, the TRAIL receptor DR4, RASSF1A, and XAF1 are epigenetically silenced in melanomas (Reu et al., 2006a, b; Bae et al., 2008), leukemia (Soncini et al., 2013), renal carcinoma (Reu et al., 2006a) and experimentally transformed cells (Lund et al., 2011). This evidence concerns the gene TNFSF10 and leukemia.