Although the role of CD8α+ resident DCs in generation of tissue-specific SLECs in some types of infections has been documented (6), peripheral tissue-derived migratory DCs (CD207+CD103+ and CD11b+CD207−CD103−dermal DCs and CD207+CD103− Langerhans cells, LCs) likely represent major players involved in processing and transfer of skin-specific information during priming and cross-priming processes (6, 7). The gene discussed is ITGAE; the disease is infection.