SLE problems that are possibly related to high serum IFN levels include lymphopenia, myalgia and muscle weakness, joint pain with modest infusions, significant constitutional symptoms – headache, body ache, malaise, and fatigue that can herald neuropsychiatric problems (poor memory, mood swings, seizures, and psychosis – without strokes or vasculitis, although there is underlying small vessel vasculopathy in SLE brains). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.