MAGI2 and inflammatory bowel disease: Interestingly, CD patients, carrying MAGI2 variants associated with IBD, display higher serum levels of antibodies against antigens from intestinal microorganisms, such as anti-Saccharomyces cerevisiae (ASCA), anti-CBir1 flagellin (CBir1), and anti-outer membrane porin C (OmpC) (94), further confirming the central role of intestinal barrier function in the pathogenesis of IBD.