Analysis of quantitative trait locus mapping of C3H/HeJBir mice backcrossed with IL-10 KO mice identified several potential colitogenic loci on chromosome 3, 1, 2, 8, 17, and 18, named, respectively, cytokine deficiency-induced colitis susceptibility 1–6 (Cdcs1–6) (10). The gene discussed is IL10; the disease is colitis.