ITGB1 and colitis: Nevertheless, in subsequent studies examining the role of HIF-1α stabilization in mucosal response to colitis in murine models, we have demonstrated that stabilization of HIF-1α through prolyl hydroxylase inhibition (PHDi) results in earlier and increased epithelial ITGB1 expression, concurrent with accelerated mucosal healing and restitution of epithelial barrier function (86).