For example, in the treatment of Alzheimer’s disease, other pharmacological cholinergic agents such as donepezil (an acetylcholine esterase inhibitor) are already used with a certain success, possibly leading to positive behavioral effects via improvement of attentional functions (Levy et al., 2000; Mansvelder et al., 2006; Heishman et al., 2010). This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.