Reduced [18F]-fluoro-L-DOPA uptake (indicating a reduced binding to the DA transporter, DAT) was detected in the basal ganglia of patients suffering of ring20 epilepsy (Biraben et al., 2004; Del Sole et al., 2010), resistant generalized “absence-like” epilepsy and drug-resistant TLE with hippocampal sclerosis (Bouilleret et al., 2005). The gene discussed is SLC6A3; the disease is epilepsy.