DRD1 and autosomal dominant nocturnal frontal lobe epilepsy: For example, positron emission tomography (PET) with [11C]-SCH23390 revealed a reduced striatal D1R binding in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE; Fedi et al., 2008), suggesting that neurotransmitter alterations in nigrostriatal DA circuits may contribute to nocturnal paroxysmal motor activity in ADNFLE.