Data reported in this review were identified by searches of PubMed (as of August 6, 2013) with the terms “dopamine AND seizure,” “dopamine AND epilepsy,” “dopamine AND epileptogenesis,” “dopamine agonist AND seizure,” “dopamine AND mTOR,” “mTOR AND epilepsy,” and “glycogen synthase kinase AND epilepsy.” Abstracts and reports from meetings were not included, and only papers published in English were reviewed. The gene discussed is MTOR; the disease is epilepsy.