FGF1 and epilepsy: The production and release of many members of the FGF family have been reported to be altered (increased in most cases) in epilepsy: these include FGF1, −2 and −5 (Gómez-Pinilla et al., 1995; Riva et al., 1995; Cuevas and Giménez-Gallego, 1996; Simonato et al., 1998; Bregola et al., 2000), FGF7 and −22 (Terauchi et al., 2010; Lee et al., 2012) FGF8 and −17 (McCabe et al., 2011; Zanni et al., 2011), as well as FHF4 (Hu et al., 2011) and α-Klotho (Park et al., 2009).