KCND2 and epilepsy: The relevance of Kv4.2 to epilepsy comes from the identification of a mutation in a patient with TLE, which results in the expression of a truncated Kv4.2 subunit (Singh et al., 2006, Table 1), and the observation that pharmacological blockade of Kv4 channels is epileptogenic (Avoli, 2001).