Individuals harboring loss-of-function mutations in KCNJ2 (e.g., Andersen-Tawil syndrome; OMIM 170390) may present with mood disorders and seizures (Haruna et al., 2007; Chan et al., 2010, Table 1), suggesting a possible role for Kir2.1 channels in the pathogenesis of neuropsychiatric disorders and epilepsy (Haruna et al., 2007; Chan et al., 2010). This evidence concerns the gene KCNJ2 and Cardiodysrhythmic potassium-sensitive periodic paralysis.