KCNMA1 and idiopathic generalized epilepsy: Interestingly, a KCaβ3 single-nucleotide mutation, causing a loss-of-function of KCa1.1 current containing the KCaβ3b subunit, displays a small but significant association with idiopathic generalized epilepsy (Hu et al., 2003; Lorenz et al., 2007, Table 1).