Therefore, the finding that CASK can regulate CaMKII autophosphorylation suggests that this mechanism may have a role in the cognitive deficits induced by CASK mutation in humans (Froyen et al., 2007; Najm et al., 2008; Piluso et al., 2009; Tarpey et al., 2009). The gene discussed is CAMK2G; the disease is Cognitive impairment.