LEP and hypertensive disorder: In this way, the oral dose of Guanabenz was simultaneously controlling hypertension as well as expression of a bifunctional therapeutic peptide hormone, GLP-1-Leptin, which combines the anorexic and insulin secretion-stimulating effect of the glucagon-like peptide 1 (GLP-1) with the lipid level, food intake- and body weight-controlling capacity of leptin.