GFAP and Alzheimer disease: Considering our previous results showing a decrease in the GFAP-IR in astroglia in AD (Olabarria et al., 2010; Rodriguez and Verkhratsky, 2011; Kulijewicz-Nawrot et al., 2012) we may suggest that it is indeed the down-regulation of GFAP which may trigger/force the changes in GS distribution and expression level.