Altered glutamatergic signaling, resulting from alterations in the expression of glutamate transporters (vesicular glutamate transporters VGLUT1/2 EAAT1/GLAST and EAAT2/GLT-1) and relevant enzymes [GS, GSLP (GS-like protein), PAG (phosphate-activated glutaminase), GDH (glutamate dehydrogenase)], as well as changes in the protein levels of specific subunits of ionotropic and metabotropic glutamate receptors, is likely to be involved in the neuronal pathology observed in AD (Miguel-Hidalgo et al., 2002; Burbaeva et al., 2005; Revett et al., 2012). The gene discussed is GLUL; the disease is Alzheimer disease.