MDA-MB-231 (BC) and A498 showed no transcriptional regulation of the two classical hypoxia inducible genes whereas KM12 (CRC) and H522 (NSCLC) demonstrated induction of only GLUT1. HS-578 T (BC) responded to the hypoxic environment with a 2.7-fold increase of VEGFA over the normoxic control and 2.8-fold change for GLUT1 (p = 0.05). The gene discussed is SESN2; the disease is colorectal carcinoma.