HNF4A and hepatocellular carcinoma: In addition, it was also introduced that the expression of HNF4alpha could directly induce the MET in fibroblasts (NIH3T3 cells) [9], and Utilizing rat hepatoma cell lines, Natalia L Lazarevich et al also proved that dedifferentiated hepatoma cells can be induced to transform to the epithelial phenotype by re-expression of HNF4alpha [28].