Now, the role of HNF4alpha in the expression regulation of E-cadherin in the HCC cells with mesenchymal phenotypes was further confirmed in our study via transfection, as it was found that the expression of E-cadherin increased accordingly when SK-Hep-1 cells were transfected with human HNF4alpha expression vector. Here, HNF4A is linked to hepatocellular carcinoma.