As for HCC, it was revealed in the Asayama Y’s study that the expression of E-cadherin in intrahepatic metastases was similar with those of primary lesions in most cases, while in two cases with reduced E-cadherin expression in the primary sites, the expression of E-cadherin in intrahepatic metastases was even preserved [6]. The gene discussed is CDH1; the disease is hepatocellular carcinoma.