CDH1 and hepatocellular carcinoma: Furthermore, the examination of HNF4alpha and E-cadherin expression in four HCC cell lines revealed again the association of E-cadherin expression with the HNF4alpha expression, and it was found that increased expression of HNF4alpha in SK-Hep-1 cells could result in an increased expression of E-cadherin, confirming the role of HNF4alpha in the regulation of E-cadherin expression.