CDH1 and neoplasm: It was found that comparing with these normal tumor-adjacent tissues, the expression of E-cadherin in the primary tumors was all down-regulated (Figure 1C), and in the metastases most of E-cadherin expression were also slightly reduced, though in some cases (19.4%, 6/31) the expression of E-cadherin in the metastases was similar with that in the normal tissues (Figure 1C).