Moreover, using a cut-off value of 100 μg/ml for the 2-hour urinary NGAL concentration, the area under the curve (AUC) was 0.95, sensitivity 82% and specificity 90% for prediction of AKI [30]; since only two patients of the UBS group had urinary NGAL values higher than 100, we can hypothesized that the perioperative use of HES130/0.42 diluted in balanced solution could be considered safe for the renal function in patients with normal preoperative renal function. The gene discussed is LCN2; the disease is acute kidney injury.