FCGR2A and infection: Alternatively, the risk of ADE of infection could be overtaken by the removal of the Ab heavy chain (i.e., the CH2 and CH3 portions or direct expression of the mAb as a Fab fragment) and/or deletion of the N-linked sugars on IgG molecules that are both required for interactions with Fc-γ receptors (Fc-γR), or eventually, by the blocking of Fc-γR engagement with anti-Fc-γR Abs [70].