Because natural mutations in TREM2 and DAP12 lead to demyelinating disease in humans and these genes are associated with demyelination in this model, we chose to study the expression of TREM2 and DAP12 mRNA expression levels in the brain, spinal cord, and liver in 33-dpi infected and mock-infected animals (Figure 4A). The gene discussed is TYROBP; the disease is demyelinating disease.