This study retrospectively analyzes the predictive value on both response to treatment and survival of BRCA1, ERCC1, ATP7B, PKM2, TOPOI, TOPΟ-IIA, TOPOIIB and C-MYC mRNA levels, as they are detected by real-time PCR in SCLC patients treated with platinum-based combination chemotherapy with or without chest radiotherapy. This evidence concerns the gene MYC and small cell lung carcinoma.