MAP1LC3A and hepatocellular carcinoma: The integrated optical density (IOD) of LC3 staining in intravascular metastases, intrabiliary metastases, bone metastases, lymph node metastases and lung metastases were 336680±44698, 558220±99102, 394083±53541, 166563±51412 and 214122±56033, which were significantly higher than those in paired primary HCC tumors (118833±12056, 126490±33543, 62472±15257, 43763±12761 and 55144±13662, respectively) (all P<0.001) (Figure 1).