NFKB1 and Hyperglycemia: Moreover, since hyperglycemia is able to activate NF-κB in endothelial cells, pericytes and vascular smooth muscle cells [26]–[30], and NF-κB activation might be involved in AR downregulation [25], [31], we examined whether hyperglycemia could reduce AR levels through NF-κB activation in LNCaP cells.