The aims of the current study are: (1) to determine whether FADD deletion may promote cardiac function recovery during the acute phase after myocardial ischemia/reperfusion (I/R); (2) to determine whether FADD deletion may rescue cardiomyocytes from cell death during the acute phase after I/R; (3) to determine whether FADD deletion may delay long-term ischemia induced heart failure; and (4) to determine whether FADD deletion may decrease long-term myocardial ischemia induced cardiac tissue death. This evidence concerns the gene FADD and myocardial ischemia.