ORAI3 and lung cancer: Figure 5C–D shows the cell cycle distribution of NCI-H23 and NCI-H460 lung cancer cells. Orai3 silencing led to cell cycle arrest, with cell accumulation in the G0/G1 phase (61.4±2.7% vs 48.8±2.8%, p<0.001 for NCI-H23, Fig. 5C, and 68±3.4% vs 52±5.1%, p<0.001 for NCI-H460, Fig. 5D). At the same time, a decrease in cell number in S and G2/M phases has been observed in both NCI-H23 and NCI-H460 cells transfected with si-Orai3 (Fig. 5C–D).