SST and bipolar disorder: Studies in subjects with bipolar disorder indicate decreases in somatostatin cellular density in the caudal entorhinal cortex and parasubiculum (Wang et al., 2011), number of somatostatin-expressing neurons in the hippocampus (Konradi et al., 2011b), somatostatin gene expression in the dlPFC (trend level; Sibille et al., 2011) and hippocampus (Konradi et al., 2011b).