Somatostatin deficits in schizophrenia are demonstrated by a reduction of CSF somatostatin (Bissette et al., 1986; Reinikainen et al., 1990), decreased somatostatin gene expression in the dlPFC (Morris et al., 2008; Guillozet-Bongaarts et al., 2013), and decreased number and density of somatostatin-expressing neurons in the hippocampus (Konradi et al., 2011a), caudal entorhinal cortex and parasubiculum (Wang et al., 2011). The gene discussed is SST; the disease is schizophrenia.