A primate-specific single nucleotide polymorphism (SNP) in the human somatostatin gene [C/T polymorphism (rs4988514)] is associated with increased risk in Alzheimer’s disease progression and additive effect with the APOE epsilon4 allele(Vepsalainen et al., 2007; Xue et al., 2009), although this was not confirmed in larger genome-wide association studies (GWAS) (Hollingworth et al., 2011; Guerreiro et al., 2013). The gene discussed is SST; the disease is early-onset autosomal dominant Alzheimer disease.