Human post-mortem studies from our group have described region-specific somatostatin deficits in MDD patients, including a down-regulation of somatostatin gene expression in the dorsolateral prefrontal cortex (dlPFC), subgenual anterior cingulate cortex (sgACC), and amygdala (Sibille et al., 2011; Tripp et al., 2011, 2012; Guilloux et al., 2012). The gene discussed is SST; the disease is major depressive disorder.