We have demonstrated the association between polymorphism in genes encoding enzymes regulating iron homeostasis including transferrin gene and the iron-regulatory protein-1 and -2 genes as well as in the generation and removal of iron-mediated oxidation: NQO1, NOS3 and NFE2L2 and the occurrence of AMD (Wysokinski et al. 2013; Synowiec et al. 2012, 2013).We have also found that the serum level of transferrin was higher in AMD patients when compared with those without AMD (Wysokinski et al. 2013). The gene discussed is NFE2L2; the disease is age-related macular degeneration.