The multiple analysis of polymorphic sites in the MnSOD (rs1799725, rs2758330, rs1967802), CAT (rs480575, rs1408035, rs769217, rs2284367) and Gpx1 (rs3448, rs3811699) genes conducted on a Northern Irish population showed no significant association with AMD (Esfandiary et al. 2005). This evidence concerns the gene CAT and age-related macular degeneration.