TF and age-related macular degeneration: We have demonstrated the association between polymorphism in genes encoding enzymes regulating iron homeostasis including transferrin gene and the iron-regulatory protein-1 and -2 genes as well as in the generation and removal of iron-mediated oxidation: NQO1, NOS3 and NFE2L2 and the occurrence of AMD (Wysokinski et al. 2013; Synowiec et al. 2012, 2013).We have also found that the serum level of transferrin was higher in AMD patients when compared with those without AMD (Wysokinski et al. 2013).