In addition, BCR signaling has been postulated to have a role for CLL trafficking and interaction with the stromal microenvironment.7 However, since our initial publication,8 where we succeeded to show that there was a 10-fold decrease in the expression of membrane Igs, we recently could demonstrate that this poor expression was the consequence of an important defect in the assembly of the BCR.9 In addition, it is clear that when stimulated through the BCR pathway, the response of CLL cells is impaired. Here, BCR is linked to B-cell chronic lymphocytic leukemia.