CFTR and bacterial infectious disease: The finding that RSV infection leads to a pronounced decrease in CFTR function at the cell surface (Figure 3) merits further investigative studies using primary human airway cells as depressed CFTR function identifies further disruption of normal airway surface liquid and PCL homeostasis, which could predispose to increased mucus viscosity, defective mucous clearance and exacerbation of secondary bacterial infection in non-CF airways in vivo.