Overall these findings regarding increased risk of hypoglycaemia with use of insulin and sulfonylureas were verified in a recent systematic review of the literature, which compared these two conventional treatments with metformin, pioglitazone, alpha-glucosidase inhibitors, incretin mimetics (DPP4-Inhibitors, GLP1-analogues), and bile acid sequestrants during treatment of T2D [87]. The gene discussed is INS; the disease is type 2 diabetes mellitus.