X-linked syndromic intellectual disability type Nascimento (MIM #300860) was first described as a distinct entity in 2006 by Nascimento and colleagues [3], who found a nonsense mutation in UBE2A (MIM *312180, alternative acronyms RAD6A, HHR6A) in three intellectually disabled males of a two generation family. Here, UBE2A is linked to syndromic X-linked intellectual disability Nascimento type.