NOS3 and ischemic stroke: Some authors have described prothrombotic genetic polymorphisms, such as PIA2, which is a determinant of ischemic stroke in a selected high-risk hypertensive population [12], or the single-nucleotide polymorphism of human CaMKIV gene (CaMK4), which plays a pivotal role in blood pressure regulation through the control of endothelial nitric oxide synthase (eNOS) activity.