CASP9 and neoplasm: Mapping of the execution phase of apoptosis demonstrated activation of the critical executioner caspase-3 in EAC and HBL-100 cells (caspase-3-wild-type) and caspase-9 in MCF-7 cells (caspase-3 knockout), as was evident from the substantial decrease in pro-caspase-3/9 and increase in caspase-3/9 at protein levels (Figure 6F) in tumor cells co-cultured with calcarea carbonica-primed T cells for 48 hrs.