Our flow cytometry data revealed a significant increase in Annexin-V-FITC/PI-positive CD4+ T-helper and Annexin-V-FITC/7-AAD-positive CD8+ T cytotoxic cells isolated from all the compartments of EAC-bearing mice (Figure 2C), which indicates apoptotic cell death as one of the major causes behind tumor-induced depletion of T cell repertoire. The gene discussed is CD8A; the disease is neoplasm.