High-throughput screenings (Brown et al., 2001, Darnell et al., 2011, Klemmer et al., 2011, Liao et al., 2008, Miyashiro et al., 2003) have revealed that a wide array of neuronal mRNAs is targeted by FMRP, suggesting that simultaneous dysregulation of many proteins contributes to FXS. This evidence concerns the gene FMR1 and fragile X syndrome.