In conclusion, we have shown that inhibition of catalytic subunit of NADPH oxidases isoforms, that is, DUOX and NOX2 detected in IB3-1 defective CFTR cells, suppresses features of oxidative stress, which are observed in hypertonic conditions as well as the increased IL-6 and IL-8 production that could be responsible for neutrophil migration and early inflammation in the course of the CF disease. Here, CXCL8 is linked to cystic fibrosis.