In the latter cases, aggregation of certain proteins, such as Prion protein (PrP), Huntingtin (Htt), amyloid β (Aβ), α-Synuclein (SNCA) and Cu/Zn superoxide dismutase (SOD1), are mechanistically linked to neurological disorders such as prion diseases, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS) [2–8]. Here, PRNP is linked to early-onset autosomal dominant Alzheimer disease.