BTG2 and neoplasm: Indeed, the upregulation of BTG2-enhanced MnSOD expression might be one of the intracellular cooperation between APRO gene and a tumor suppressor through the regulations of cell division cycle and intracellular ROS level, since the notion was supported by luciferase assays using promoter and enhancer element of MnSOD gene and by reverse correlations of IκBα and MnSOD expression, in addition to ChIP and immunoblot analyses (Figure 2).