To further investigate the relationship between LMP-1 and SATB1 in NPC cells, a LMP-1 over-expression plasmid (PAT-LMP-1-GFP) was transfected into CEN1 cells to generate LMP-1 stably expressed NPC cell line CNE1-GL[31], then we found that forced LMP-1 expression in CNE1 cells led to a surprisingly increased SATB1 expression and nuclear location, companying with the up-regulation of PCNA (Figure 8). The gene discussed is SATB1; the disease is nasopharyngeal carcinoma.