Interestingly, circulating miR-210 levels were significantly higher in individuals with residual disease than in those who achieved a pathologically complete response to trastuzumab (Jung et al., 2012), administered at baseline before patients received neoadjuvant chemotherapy, as a part of the standard treatment for patients with human epidermal growth factor receptor 2 (HER-2)-positive breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.